Epitope mapping of CD1a, CD1b, and CD1c antigens in human skin: differential localization on Langerhans cells, keratinocytes, and basement membrane zone

M Furue, M Nindl, K Kawabe, K Nakamura… - Journal of investigative …, 1992 - Elsevier
M Furue, M Nindl, K Kawabe, K Nakamura, Y Ishibashi, K Sagawa
Journal of investigative dermatology, 1992Elsevier
CD1 antigens are classified into at least three groups, CDla, CDlb, and CDlc. In order to
delineate the localization of epitopes of CD1 antigens in human skin, we examined the
irnrnunoreactivity of fourteen different CD1 antibodies (seven CDla, five CDlb, and two CDlc
antibodies). The epitopes for CDla, CDlb, and CDlc are differentially localized on epidermal
Langerhans cells, dermal dendritic cells, keratinocytes, the luminal portion of eccrine gland
ducts, and the basement membrane zone in normal human skin.
CD1 antigens are classified into at least three groups, CDla, CDlb, and CDlc. In order to delineate the localization of epitopes of CD1 antigens in human skin, we examined the irnrnunoreactivity of fourteen different CD1 antibodies (seven CDla, five CDlb, and two CDlc antibodies). The epitopes for CDla, CDlb, and CDlc are differentially localized on epidermal Langerhans cells, dermal dendritic cells, keratinocytes, the luminal portion of eccrine gland ducts, and the basement membrane zone in normal human skin.
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