Epigenetic regulation of cardiac differentiation of embryonic stem cells and tissues

I Jebeniani, J Leschik, M Puceat - JoVE (Journal of Visualized …, 2016 - jove.com
Specific gene transcription is a key biological process that underlies cell fate decision during
embryonic development. The biological process is mediated by transcription factors which
bind genomic regulatory regions including enhancers and promoters of cardiac constitutive
genes. DNA is wrapped around histones that are subjected to chemical modifications.
Modifications of histones further lead to repressed, activated or poised gene transcription,
thus bringing another level of fine tuning regulation of gene transcription. Embryonic Stem …