Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: role of mitochondrial permeability …
R Ye, Q Yang, X Kong, N Li, Y Zhang, J Han… - Critical care …, 2012 - journals.lww.com
Objective: Anesthetic preconditioning appears to be a viable strategy to treat ischemic
cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane
preconditioning sustains in time; 2) whether sevoflurane preconditioning diminishes
mitochondrial dysfunction following cerebral ischemia; and 3) whether mitochondrial
permeability transition pore plays a crucial role in the sevoflurane preconditioning. Design:
Laboratory investigation. Setting: University research laboratory. Subjects: Sprague-Dawley …
cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane
preconditioning sustains in time; 2) whether sevoflurane preconditioning diminishes
mitochondrial dysfunction following cerebral ischemia; and 3) whether mitochondrial
permeability transition pore plays a crucial role in the sevoflurane preconditioning. Design:
Laboratory investigation. Setting: University research laboratory. Subjects: Sprague-Dawley …