Human albumin improves long-term behavioral sequelae after subarachnoid hemorrhage through neurovascular remodeling

Y Xie, W Liu, X Zhang, L Wang, L Xu, Y Xiong… - Critical care …, 2015 - journals.lww.com
Objective: Subarachnoid hemorrhage results in significant long-lasting neurologic sequelae.
Here, we investigated whether human albumin improves long-term outcomes in
experimental subarachnoid hemorrhage and whether neurovascular remodeling is involved
in the protection of albumin. Design: Laboratory investigation. Setting: Hospital research
laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Rats underwent
subarachnoid hemorrhage by endovascular perforation. Albumin of either 0.63 or 1.25 g/kg …