Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse
G Quan, C Xie, JM Dietschy, SD Turley - Developmental brain research, 2003 - Elsevier
These studies characterized the ontogenesis and regulation of cholesterol turnover in the
central nervous system (CNS) of mice. During the first 3 weeks after birth, the CNS grew
rapidly and equaled 5% of body weight. The cholesterol pool in this tissue expanded at a
rate of 0.26 mg/day and the CNS synthesized sterol at a rate of 0.28 mg/day. In mature mice
between 13 and 26 weeks of age, there was a marked decrease in these parameters
including a reduction in the relative size of the CNS to 1.7% of body weight, a decrease in …
central nervous system (CNS) of mice. During the first 3 weeks after birth, the CNS grew
rapidly and equaled 5% of body weight. The cholesterol pool in this tissue expanded at a
rate of 0.26 mg/day and the CNS synthesized sterol at a rate of 0.28 mg/day. In mature mice
between 13 and 26 weeks of age, there was a marked decrease in these parameters
including a reduction in the relative size of the CNS to 1.7% of body weight, a decrease in …