[HTML][HTML] Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast …
L Duan, N Motchoulski, B Danzer, I Davidovich… - Journal of biological …, 2011 - ASBMB
Endocrine therapy with tamoxifen (TAM) significantly improves outcomes for patients with
estrogen receptor-positive breast cancer. However, intrinsic (de novo) or acquired
resistance to TAM occurs in a significant proportion of treated patients. To identify genes
involved in resistance to TAM, we introduced full-length cDNA expression library into
estrogen receptor-positive MCF7 cells and exposed them to a cytotoxic dose of 4-
hydroxytamoxifen (4OHTAM). Four different library inserts were isolated from surviving …
estrogen receptor-positive breast cancer. However, intrinsic (de novo) or acquired
resistance to TAM occurs in a significant proportion of treated patients. To identify genes
involved in resistance to TAM, we introduced full-length cDNA expression library into
estrogen receptor-positive MCF7 cells and exposed them to a cytotoxic dose of 4-
hydroxytamoxifen (4OHTAM). Four different library inserts were isolated from surviving …