[HTML][HTML] Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3′-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake …
The precise mechanism by which insulin regulates glucose metabolism is not fully
understood. However, it is known that insulin activates two enzymes, phosphatidylinositol
3′-kinase (PI 3′-K) and mitogen-activated protein kinase (MAPK), which may be involved
in stimulating the metabolic effects of insulin. The role of these enzymes in glucose
metabolism was examined by comparing the effects of insulin, platelet-derived growth factor
(PDGF) and epidermal growth factor (EGF) in 3T3-L1 adipocytes. Treatment of the cells with …
understood. However, it is known that insulin activates two enzymes, phosphatidylinositol
3′-kinase (PI 3′-K) and mitogen-activated protein kinase (MAPK), which may be involved
in stimulating the metabolic effects of insulin. The role of these enzymes in glucose
metabolism was examined by comparing the effects of insulin, platelet-derived growth factor
(PDGF) and epidermal growth factor (EGF) in 3T3-L1 adipocytes. Treatment of the cells with …