[HTML][HTML] Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
K De Fea, RA Roth - Journal of Biological Chemistry, 1997 - ASBMB
Increased serine phosphorylation of insulin receptor substrate-1 (IRS-1) has been observed
in several systems to correlate with a decreased ability of the insulin receptor to tyrosine-
phosphorylate this endogenous substrate and to inhibit its subsequent association with
phosphatidylinositol 3-kinase. In the present studies we have examined the potential role of
the mitogen-activated protein (MAP) kinase in the increased serine phosphorylation of IRS-1
observed in human embryonic kidney cells treated with an activator of protein kinase C …
in several systems to correlate with a decreased ability of the insulin receptor to tyrosine-
phosphorylate this endogenous substrate and to inhibit its subsequent association with
phosphatidylinositol 3-kinase. In the present studies we have examined the potential role of
the mitogen-activated protein (MAP) kinase in the increased serine phosphorylation of IRS-1
observed in human embryonic kidney cells treated with an activator of protein kinase C …