[HTML][HTML] Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription

K Chakravarty, P Leahy, D Becard, P Hakimi… - Journal of Biological …, 2001 - ASBMB
We have assessed the potential role of sterol regulatory element-binding protein-1c (SREBP-
1c) on the transcription of the gene for the cytosolic form of phosphoenolpyruvate
carboxykinase (GTP)(EC 4.1. 1.32)(PEPCK-C). SREBP-1c introduced into primary
hepatocytes with an adenovirus vector caused a total loss of PEPCK-C mRNA and a marked
induction of fatty acid synthase mRNA that directly coincided with the appearance of SREBP-
1c in the hepatocytes. It also blocked the induction of PEPCK-C mRNA by cAMP and …