Post-translational processing and activation of insulin and EGF proreceptors
MD Lane, G Ronnett, LJ Slieker, RA Kohanski… - Biochimie, 1985 - Elsevier
We have investigated the role of glycosylation on the post-translational processing of the
insulin, and EGF proreceptor polypeptides. Following translation of the insulin proreceptor,
by 3T3-L1 adipocytes, about 1.5 h are required for its conversion into active receptor; an
additional 1.5 h are needed for the active receptor to reach the plasma membrane. During
this 3-hour period the proreceptor undergoes a complex series of processing events,
glycosylation being an essential processing step. Thus, treatment of 3T3-L1 adipocytes with …
insulin, and EGF proreceptor polypeptides. Following translation of the insulin proreceptor,
by 3T3-L1 adipocytes, about 1.5 h are required for its conversion into active receptor; an
additional 1.5 h are needed for the active receptor to reach the plasma membrane. During
this 3-hour period the proreceptor undergoes a complex series of processing events,
glycosylation being an essential processing step. Thus, treatment of 3T3-L1 adipocytes with …