C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma
JX Di, HY Zhang - Anti-Cancer Drugs, 2019 - journals.lww.com
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) is
complicated in the tumor progression of multiple cancers including human head and neck
squamous cell carcinoma (HNSCC) and, therefore, serves as a potent therapeutic target. In
this study, we identify that C188-9, a small-molecule STAT3 inhibitor, exhibits an antitumor
effect on HNSCC in vitro. C188-9 significantly inhibits cell growth, arrests cell cycle at G0/G1
phase, and induces apoptosis in HNSCC. Besides, the capacities of migration and invasion …
complicated in the tumor progression of multiple cancers including human head and neck
squamous cell carcinoma (HNSCC) and, therefore, serves as a potent therapeutic target. In
this study, we identify that C188-9, a small-molecule STAT3 inhibitor, exhibits an antitumor
effect on HNSCC in vitro. C188-9 significantly inhibits cell growth, arrests cell cycle at G0/G1
phase, and induces apoptosis in HNSCC. Besides, the capacities of migration and invasion …