Thrombocytopenia in c-mpl-Deficient Mice
AL Gurney, K Carver-Moore, FJ de Sauvage… - Science, 1994 - science.org
AL Gurney, K Carver-Moore, FJ de Sauvage, MW Moore
Science, 1994•science.orgThrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production.
The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in
regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting.
The c-mpl-/-mice had an 85 percent decrease in their number of platelets and
megakaryocytes but had normal amounts of other hematopoietic cell types. These mice also
had increased concentrations of circulating TPO. These results show that c-mpl specifically …
The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in
regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting.
The c-mpl-/-mice had an 85 percent decrease in their number of platelets and
megakaryocytes but had normal amounts of other hematopoietic cell types. These mice also
had increased concentrations of circulating TPO. These results show that c-mpl specifically …
Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-mpl-/- mice had an 85 percent decrease in their number of platelets and megakaryocytes but had normal amounts of other hematopoietic cell types. These mice also had increased concentrations of circulating TPO. These results show that c-mpl specifically regulates megakaryocytopoiesis and thrombopoiesis through activation by its ligand TPO.
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