Insulin resistance, skin changes, and virilization: a recessively inherited syndrome possibly due to pineal gland dysfunction

ND Barnes, PJ Palumbo, AB Hayles, H Folgar - Diabetologia, 1974 - Springer
ND Barnes, PJ Palumbo, AB Hayles, H Folgar
Diabetologia, 1974Springer
A syndrome of glucose intolerance associated with hyperinsulinaemia and insulin
resistance, skin changes, and mild virilization occurred in two daughters of a first-cousin
marriage. The condition is probably inherited as an autosomal recessive trait. It is likely to
represent a widespread disturbance in neuro-endocrine control; the primary metabolic error
may involve pineal, virilization.
Summary
A syndrome of glucose intolerance associated with hyperinsulinaemia and insulin resistance, skin changes, and mild virilization occurred in two daughters of a first-cousin marriage. The condition is probably inherited as an autosomal recessive trait. It is likely to represent a widespread disturbance in neuro-endocrine control; the primary metabolic error may involve pineal, virilization.
Springer