[HTML][HTML] p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic …

EN Gurzov, CM Germano, DA Cunha, F Ortis… - Journal of Biological …, 2010 - ASBMB
Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and
pancreatic β-cell loss. Here, we demonstrate that the proinflammatory cytokine interleukin-
1β, combined with interferon-γ, induces the expression of the Bcl-2 homology 3 (BH3)-only
activator PUMA (p53 up-regulated modulator of apoptosis) in β-cells. Transcriptional
activation of PUMA is regulated by nuclear factor-κB and endoplasmic reticulum stress but is
independent of p53. PUMA activation leads to mitochondrial Bax translocation, cytochrome c …