4E-BP1, a multifactor regulated multifunctional protein

X Qin, B Jiang, Y Zhang - Cell cycle, 2016 - Taylor & Francis
X Qin, B Jiang, Y Zhang
Cell cycle, 2016Taylor & Francis
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of
a family of translation repressor proteins, and a well-known substrate of mechanistic target of
rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from
eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be
phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found
in different human carcinomas. In this review, we summarize the novel findings on mTOR …
Abstract
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.
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