HSF expression in skeletal muscle during myogenesis: implications for failed regeneration in old mice
A McArdle, CS Broome, AC Kayani, MD Tully… - Experimental …, 2006 - Elsevier
The ability of muscles of old mice to recover force generation following substantial damage
is severely impaired, particularly during the late phase of regeneration. This inability to
recover successfully may be associated with the attenuated ability of muscles of old mice to
produce heat shock proteins (HSPs) in response to stress since muscles of old mice
overexpressing HSP70 recover successfully following damage. The capacity of mature
mammalian skeletal muscle to regenerate following damage is due to the presence of …
is severely impaired, particularly during the late phase of regeneration. This inability to
recover successfully may be associated with the attenuated ability of muscles of old mice to
produce heat shock proteins (HSPs) in response to stress since muscles of old mice
overexpressing HSP70 recover successfully following damage. The capacity of mature
mammalian skeletal muscle to regenerate following damage is due to the presence of …