Characterization of age-related changes in natural killer cells during primary influenza infection in mice
S Nogusa, BW Ritz, SH Kassim, SR Jennings… - Mechanisms of ageing …, 2008 - Elsevier
The current investigation examined the importance of natural killer (NK) cells during the
innate immune response to primary influenza infection in young and aged mice. Young (6–8
weeks) and aged (22 months) C57BL/6 mice were infected intranasally with influenza A
virus, and NK cell-mediated cytotoxicity was determined in lung and spleen during the first 4
days of infection. Aged mice demonstrated both a decrease in influenza-inducible NK
activity and a reduction in the percentage and number of NK1. 1+ cells in response to …
innate immune response to primary influenza infection in young and aged mice. Young (6–8
weeks) and aged (22 months) C57BL/6 mice were infected intranasally with influenza A
virus, and NK cell-mediated cytotoxicity was determined in lung and spleen during the first 4
days of infection. Aged mice demonstrated both a decrease in influenza-inducible NK
activity and a reduction in the percentage and number of NK1. 1+ cells in response to …