Age-related changes in natural killer cell receptors from childhood through old age
A Almeida-Oliveira, M Smith-Carvalho, LC Porto… - Human immunology, 2011 - Elsevier
Most studies on natural killer (NK) cells and aging have focused on overall cell numbers and
global cytotoxic activity. NK cell functions are controlled by surface receptors belonging to
three major families: killer cell immunoglobulin-like receptors (KIRs), natural cytotoxicity
receptors (NCRs), and C-type lectins. The expression of these receptors was investigated
from childhood through old age in T, NKT-and NK cells and also in the CD56dim (cytotoxic)
and CD56bright (responsible for cytokine production) NK cell subsets. A decrease in the …
global cytotoxic activity. NK cell functions are controlled by surface receptors belonging to
three major families: killer cell immunoglobulin-like receptors (KIRs), natural cytotoxicity
receptors (NCRs), and C-type lectins. The expression of these receptors was investigated
from childhood through old age in T, NKT-and NK cells and also in the CD56dim (cytotoxic)
and CD56bright (responsible for cytokine production) NK cell subsets. A decrease in the …