Highlights•Animal coronaviruses can cause severe respiratory illness and death in
humans.•Coronavirus vaccines and antiviral drugs are not yet available.•Animal models are
needed to study pathogenesis and evaluate vaccines and antivirals.•No single animal
model can be used to study both SARS and MERS coronaviruses.•The most appropriate
animal model should be selected to meet experimental goals.The emergence of Severe
Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory …