The emergence of the highly pathogenic SARS coronavirus (SARS-CoV) has reignited
interest in coronavirus biology and pathogenesis. An emerging theme in coronavirus
pathogenesis is that the interaction between specific viral genes and the host immune
system, specifically the innate immune system, functions as a key determinant in regulating
virulence and disease outcomes. Using SARS-CoV as a model, we will review the current
knowledge of the interplay between coronavirus infection and the host innate immune …