The role of senescent cells in ageing

JM Van Deursen - Nature, 2014 - nature.com
JM Van Deursen
Nature, 2014nature.com
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its
known role to complex biological processes such as development, tissue repair, ageing and
age-related disorders. New insights indicate that, unlike a static endpoint, senescence
represents a series of progressive and phenotypically diverse cellular states acquired after
the initial growth arrest. A deeper understanding of the molecular mechanisms underlying …
Abstract
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
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