Cerebral germinomas and klinefelter syndrome. A review

R Arens, D Marcus, S Engelberg, G Findler… - Cancer, 1988 - Wiley Online Library
R Arens, D Marcus, S Engelberg, G Findler, RM Goodman, JH Passwell
Cancer, 1988Wiley Online Library
Patients with Klinefelter syndrome appear to be predisposed to the development of
extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years
of age with Klinefelter syndrome is documented in this article. In view of three other cases of
cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for
this predisposition is suggested.
Abstract
Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.
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