[HTML][HTML] Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody
P Prabakaran, J Gan, Y Feng, Z Zhu… - Journal of Biological …, 2006 - ASBMB
The severe acute respiratory syndrome coronavirus (SARS-CoV, or SCV), which caused a
world-wide epidemic in 2002 and 2003, binds to a receptor, angiotensin-converting enzyme
2 (ACE2), through the receptor-binding domain (RBD) of its envelope (spike, S)
glycoprotein. The RBD is very immunogenic; it is a major SCV neutralization determinant
and can elicit potent neutralizing antibodies capable of out-competing ACE2. However, the
structural basis of RBD immunogenicity, RBD-mediated neutralization, and the role of RBD …
world-wide epidemic in 2002 and 2003, binds to a receptor, angiotensin-converting enzyme
2 (ACE2), through the receptor-binding domain (RBD) of its envelope (spike, S)
glycoprotein. The RBD is very immunogenic; it is a major SCV neutralization determinant
and can elicit potent neutralizing antibodies capable of out-competing ACE2. However, the
structural basis of RBD immunogenicity, RBD-mediated neutralization, and the role of RBD …