[HTML][HTML] Critical role of cAMP-GEFII· Rim2 complex in incretin-potentiated insulin secretion
Y Kashima, T Miki, T Shibasaki, N Ozaki… - Journal of Biological …, 2001 - ASBMB
Incretins such as glucagon-like peptide-1 and gastric inhibitory polypeptide/glucose-
dependent insulinotropic peptide are known to potentiate insulin secretion mainly through a
cAMP/protein kinase A (PKA) signaling pathway in pancreatic β-cells, but the mechanism is
not clear. We recently found that the cAMP-binding protein cAMP-GEFII (or Epac 2),
interacting with Rim2, a target of the small G protein Rab3, mediates cAMP-dependent, PKA-
independent exocytosis in a reconstituted system. In the present study, we investigated the …
dependent insulinotropic peptide are known to potentiate insulin secretion mainly through a
cAMP/protein kinase A (PKA) signaling pathway in pancreatic β-cells, but the mechanism is
not clear. We recently found that the cAMP-binding protein cAMP-GEFII (or Epac 2),
interacting with Rim2, a target of the small G protein Rab3, mediates cAMP-dependent, PKA-
independent exocytosis in a reconstituted system. In the present study, we investigated the …