[HTML][HTML] A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular …

V Joukov, V Kumar, T Sorsa, E Arighi, H Weich… - Journal of Biological …, 1998 - ASBMB
The vascular endothelial growth factor (VEGF) and the VEGF-C promote growth of blood
vessels and lymphatic vessels, respectively. VEGF activates the endothelial VEGF receptors
(VEGFR) 1 and 2, and VEGF-C activates VEGFR-3 and VEGFR-2. Both VEGF and VEGF-C
are also potent vascular permeability factors. Here we have analyzed the receptor binding
and activating properties of several cysteine mutants of VEGF-C including those (Cys 156
and Cys 165), which in other platelet-derived growth factor/VEGF family members mediate …