[HTML][HTML] IL-22 is required for the induction of bronchus-associated lymphoid tissue in tolerant lung allografts
S Tanaka, JM Gauthier, A Fuchs, W Li, AY Tong… - American Journal of …, 2020 - Elsevier
Long-term survival after lung transplantation remains profoundly limited by graft rejection.
Recent work has shown that bronchus-associated lymphoid tissue (BALT), characterized by
the development of peripheral nodal addressin (PNAd)-expressing high endothelial venules
and enriched in B and Foxp3+ T cells, is important for the maintenance of allograft tolerance.
Mechanisms underlying BALT induction in tolerant pulmonary allografts, however, remain
poorly understood. Here, we show that the development of PNAd-expressing high …
Recent work has shown that bronchus-associated lymphoid tissue (BALT), characterized by
the development of peripheral nodal addressin (PNAd)-expressing high endothelial venules
and enriched in B and Foxp3+ T cells, is important for the maintenance of allograft tolerance.
Mechanisms underlying BALT induction in tolerant pulmonary allografts, however, remain
poorly understood. Here, we show that the development of PNAd-expressing high …