[HTML][HTML] IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway
G Hu, BJ Barnes - Journal of Biological Chemistry, 2009 - ASBMB
The efficient and regulated response to cellular stress is coordinated by a genetic regulatory
network in which a given transcription factor controls the expression of diverse target genes
depending on the cell type and/or nature of the stimuli. The tumor suppressor p53 is thought
to preferentially regulate the balance between cell survival and death. The interferon
regulatory factor 5 (IRF-5), known to be involved in the innate immune response to
pathogens, is also a critical regulator of DNA damage-induced apoptosis. Here, we provide …
network in which a given transcription factor controls the expression of diverse target genes
depending on the cell type and/or nature of the stimuli. The tumor suppressor p53 is thought
to preferentially regulate the balance between cell survival and death. The interferon
regulatory factor 5 (IRF-5), known to be involved in the innate immune response to
pathogens, is also a critical regulator of DNA damage-induced apoptosis. Here, we provide …