Striatal dopamine neurotransmission is critical for normal voluntary movement, affect and
cognition. Dysfunctions of its regulation are implicated in a broad range of behaviors and
disorders including Parkinson's disease, schizophrenia and drug abuse. Extracellular
dopamine levels result from a dynamic equilibrium between release and reuptake by
dopaminergic terminals. Both processes are regulated by multiple mechanisms. Here we
review data characterizing how dopamine levels are regulated by presynaptic autoreceptors …