Intrastriatal shifts mediate the transition from drug-seeking actions to habits
A Belin-Rauscent, BJ Everitt… - Biological …, 2012 - biologicalpsychiatryjournal.com
Indeed, over the course of the development of addiction, drug seeking becomes
progressively controlled by drug-associated stimuli, acting as both conditioned reinforcers
and as pavlovian elicitors of relapse and/or craving. This may reflect the subversion by drugs
of natural instrumental learning processes, such as response-outcome and stimulus-
response instrumental learning mechanisms as well as pavlovian-instrumental interactions,
thereby facilitating the development of habitual control over drug seeking and taking (1, 2) …
progressively controlled by drug-associated stimuli, acting as both conditioned reinforcers
and as pavlovian elicitors of relapse and/or craving. This may reflect the subversion by drugs
of natural instrumental learning processes, such as response-outcome and stimulus-
response instrumental learning mechanisms as well as pavlovian-instrumental interactions,
thereby facilitating the development of habitual control over drug seeking and taking (1, 2) …