Pseudohypoparathyroidism
A Linglart, MA Levine, H Jüppner - … and Metabolism Clinics, 2018 - endo.theclinics.com
On binding of parathyroid hormone (PTH) to its receptor, the heptahelical PTH/PTHrP
receptor (PTH1R), leads to dissociation of Gsa (encoded by GNAS), the alphasubunit of the
heterotrimeric stimulatory G protein from the ßg-subunits, with subsequent activation by Gsa
of adenylyl cyclase and synthesis of the intracellular
receptor (PTH1R), leads to dissociation of Gsa (encoded by GNAS), the alphasubunit of the
heterotrimeric stimulatory G protein from the ßg-subunits, with subsequent activation by Gsa
of adenylyl cyclase and synthesis of the intracellular