[HTML][HTML] Low-dose parenteral busulfan provides an extended window for the infusion of hematopoietic stem cells in murine hosts
MM Hsieh, S Langemeijer, A Wynter, OA Phang… - Experimental …, 2007 - Elsevier
OBJECTIVE: Myeloablative total body irradiation (TBI) in the setting of autologous
transplantation of genetically modified hematopoietic stem cells (HSC) is associated with
substantial toxicity. Nonmyeloablative doses of TBI are less toxic, but result in low-level
engraftment of genetically modified HSCs. As an alternative to TBI, escalating doses of
parenteral busulfan were tested for their hematologic toxicity, their ability to promote donor
leukocyte engraftment, and the time window for such engraftment. MATERIALS AND …
transplantation of genetically modified hematopoietic stem cells (HSC) is associated with
substantial toxicity. Nonmyeloablative doses of TBI are less toxic, but result in low-level
engraftment of genetically modified HSCs. As an alternative to TBI, escalating doses of
parenteral busulfan were tested for their hematologic toxicity, their ability to promote donor
leukocyte engraftment, and the time window for such engraftment. MATERIALS AND …