Mechanical function is known to be of crucial importance for the maintenance of bone tissue.
Gravity on one hand and muscular effort on the other hand are required for normal skeletal
structure. It has been shown by numerous experimental studies that loss of total-body
calcium, and marked skeletal changes occur in people who have flown in space. However,
most of the pertinent investigations have been conducted on animal models, including rats
and non-human primates, and a reasonably clear picture of bone response to spaceflight …