[HTML][HTML] Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling

P Xia, L Wang, PAB Moretti, N Albanese, F Chai… - Journal of Biological …, 2002 - ASBMB
Tumor necrosis factor-α (TNF) receptor-associated factor 2 (TRAF2) is one of the major
mediators of TNF receptor superfamily transducing TNF signaling to various functional
targets, including activation of NF-κB, JNK, and antiapoptosis. We investigated how TRAF2
mediates differentially the distinct downstream signals. We now report a novel mechanism of
TRAF2-mediated signal transduction revealed by an association of TRAF2 with sphingosine
kinase (SphK), a lipid kinase that is responsible for the production of sphingosine 1 …