Sphingolipids are present in membranes of all eukaryotic cells. Bioactive sphingolipids also
function as signaling molecules that regulate cellular processes such as proliferation,
migration, and apoptosis. Human cytomegalovirus (HCMV) exploits a variety of cellular
signaling pathways to promote its own replication. However, whether HCMV modulates lipid
signaling pathways is an essentially unexplored area of research in virus-host cell
interactions. In this study, we examined the accumulation of the bioactive sphingolipids and …