[HTML][HTML] DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice
SA McGrath-Morrow, R Ndeh, KA Helmin… - Journal of Biological …, 2018 - ASBMB
Pediatric acute lung injury, usually because of pneumonia, has a mortality rate of more than
20% and an incidence that rivals that of all childhood cancers combined. CD4+ T-cells
coordinate the immune response to pneumonia but fail to function robustly among the very
young, who have poor outcomes from lung infection. We hypothesized that DNA methylation
represses a mature CD4+ T-cell transcriptional program in neonates with pneumonia. Here,
we found that neonatal mice (3–4 days old) aspirated with Escherichia coli bacteria had a …
20% and an incidence that rivals that of all childhood cancers combined. CD4+ T-cells
coordinate the immune response to pneumonia but fail to function robustly among the very
young, who have poor outcomes from lung infection. We hypothesized that DNA methylation
represses a mature CD4+ T-cell transcriptional program in neonates with pneumonia. Here,
we found that neonatal mice (3–4 days old) aspirated with Escherichia coli bacteria had a …