[HTML][HTML] T follicular helper cell subsets and the associated cytokine IL-21 in the pathogenesis and therapy of asthma
For many decades, T helper 2 (TH 2) cells have been considered to predominantly regulate
the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway
hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have
significantly shifted our understanding of asthma from a simple TH 2 cell-dependent disease
to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper
(T FH) cells. T FH cells, which are a specialized cell population that provides help to B cells …
the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway
hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have
significantly shifted our understanding of asthma from a simple TH 2 cell-dependent disease
to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper
(T FH) cells. T FH cells, which are a specialized cell population that provides help to B cells …
For many decades, T helper 2 (TH2) cells have been considered to predominantly regulate the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have significantly shifted our understanding of asthma from a simple TH2 cell-dependent disease to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper (TFH) cells. TFH cells, which are a specialized cell population that provides help to B cells, have attracted intensive attention in the past decade because of their crucial role in regulating antibody response in a broad range of diseases. In particular, TFH cells are essential for IgE antibody class-switching. In this review, we summarize the recent progress regarding the role of TFH cells and their signature cytokine interleukin (IL)-21 in asthma from mouse studies and clinical reports. We further discuss future therapeutic strategies to treat asthma by targeting TFH cells and IL-21.
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