Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis

BMP Tang, JC Craig, GD Eslick, I Seppelt… - Critical care …, 2009 - journals.lww.com
Objective: Controversy remains as to whether low-dose corticosteroids can reduce the
mortality and morbidity of acute lung injury (ALI) or the acute respiratory distress syndrome
(ARDS) without increasing the risk of adverse reactions. We aimed to evaluate all studies
investigating prolonged corticosteroids in low-to-moderate dose in ALI or ARDS. Data
Sources: MEDLINE, EMBASE, Current Content, and Cochrane Central Register of
Controlled Trials, and bibliographies of retrieved articles. Study Selection: Randomized …