Growth plate chondrocytes undergo a coordinated process of differentiation, regulating long
bone growth. Parathyroid hormone-like hormone (Pthlh) inhibits hypertrophic differentiation
in the growth plate chondrocytes and reduces Hedgehog (Hh) signaling. In mice lacking the
Hh mediator Suppressor of fused (Sufu), Pthlh treatment resulted in the up-regulation of Hh
activity and an increased number of hypertrophic chondrocytes. Furthermore, Pthlh
increased Sufu protein levels, and in chondrocytes lacking Sufu, it was unable to process Hh …