Interstitial cells of Cajal in the normal human gut and in Hirschsprung disease
S Gfroerer, U Rolle - Pediatric surgery international, 2013 - Springer
S Gfroerer, U Rolle
Pediatric surgery international, 2013•SpringerHirschsprung disease (HD) is the most prevalent congenital gastrointestinal motility
disorder. The pathogenesis of HD is defined as a functional intestinal obstruction resulting
from a defect in the intrinsic innervation of the distal bowel. In addition to the enteric nervous
system, the interstitial cells of Cajal (ICC) play an important role in the generation of
coordinated gastrointestinal peristalsis. The major function of the ICCs is the generation of
slow waves that allow these cells to act as specialised pacemaker cells within various …
disorder. The pathogenesis of HD is defined as a functional intestinal obstruction resulting
from a defect in the intrinsic innervation of the distal bowel. In addition to the enteric nervous
system, the interstitial cells of Cajal (ICC) play an important role in the generation of
coordinated gastrointestinal peristalsis. The major function of the ICCs is the generation of
slow waves that allow these cells to act as specialised pacemaker cells within various …
Abstract
Hirschsprung disease (HD) is the most prevalent congenital gastrointestinal motility disorder. The pathogenesis of HD is defined as a functional intestinal obstruction resulting from a defect in the intrinsic innervation of the distal bowel. In addition to the enteric nervous system, the interstitial cells of Cajal (ICC) play an important role in the generation of coordinated gastrointestinal peristalsis. The major function of the ICCs is the generation of slow waves that allow these cells to act as specialised pacemaker cells within various tissues. ICCs have additional functions in the gastrointestinal tract as regulators of mechanical activity and neurotransmission. Due to the central role of ICCs in gastrointestinal peristalsis, it has been suggested that defects or impairments of the ICCs may contribute to motility dysfunction in several gastrointestinal motility disorders. This review describes the distribution and functions of ICCs in the normal gut and in Hirschsprung disease.
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