Detection of ganglion cells in the colonic plexuses by immunostaining for neuron-specific marker NeuN: an aid for the diagnosis of Hirschsprung disease

S Yang, LR Donner - Applied Immunohistochemistry & Molecular …, 2002 - journals.lww.com
The majority of ganglion cells in the colonic plexuses can be easily and specifically
identified by immunostaining for neuronal marker NeuN. The distance between the
neighboring solitary ganglion cells or groups of ganglion cells varied from 0.18 to 4.0 mm,
average 1.0 mm, in ganglionic segments of colons of patients with Hirschsprung disease,
and from 0.3 to 6.3 mm, average 1.43 mm, in colons of pediatric patients with chronic
constipation of various etiologies. No ganglion cells were detected in aganglionic colonic …