[HTML][HTML] CXCL13-mediated recruitment of intrahepatic CXCR5+ CD8+ T cells favors viral control in chronic HBV infection
Y Li, L Tang, L Guo, C Chen, S Gu, Y Zhou, G Ye… - Journal of …, 2020 - Elsevier
Background & Aims Although CD8+ T cell exhaustion hampers viral control during chronic
HBV infection, the pool of CD8+ T cells is phenotypically and functionally heterogeneous.
Therefore, a specific subpopulation of CD8+ T cells should be further investigated. This
study aims to dissect a subset of CD8+ T cells expressing CXC motif chemokine receptor 5
(CXCR5) in chronic HBV infection. Methods The frequency of CXCR5+ CD8+ T cells and the
levels of CXC motif chemokine ligand 13 (CXCL13), a chemokine of CXCR5, were …
HBV infection, the pool of CD8+ T cells is phenotypically and functionally heterogeneous.
Therefore, a specific subpopulation of CD8+ T cells should be further investigated. This
study aims to dissect a subset of CD8+ T cells expressing CXC motif chemokine receptor 5
(CXCR5) in chronic HBV infection. Methods The frequency of CXCR5+ CD8+ T cells and the
levels of CXC motif chemokine ligand 13 (CXCL13), a chemokine of CXCR5, were …
