Dynamics of serum alpha-fetoprotein during spontaneous hepatocellular carcinoma development in mice
GL Princler, G Vlahakis, KH Kortright, S Okada… - European Journal of …, 1981 - Elsevier
Abstract C3H-A vy fB mice have been studied over their normal life span and 69%
developed hepatocellular carcinoma (HCC). Forty-seven mice were bled at monthly
intervals, and individual serum alpha-fetoprotein (AFP) profiles are presented for 36
animals. Most of these profiles are quite irregular. Sixty percent of the 15 male mice had a
transient serum AFP elevation at 5 months, reaching a mean of 289 ng/ml, compared to a
mean of 208 ng/ml for those male mice without a transient AFP elevation and a mean of 185 …
developed hepatocellular carcinoma (HCC). Forty-seven mice were bled at monthly
intervals, and individual serum alpha-fetoprotein (AFP) profiles are presented for 36
animals. Most of these profiles are quite irregular. Sixty percent of the 15 male mice had a
transient serum AFP elevation at 5 months, reaching a mean of 289 ng/ml, compared to a
mean of 208 ng/ml for those male mice without a transient AFP elevation and a mean of 185 …