Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis
CL Zuur, YJ Simis, PE Lansdaal, AA Hart… - International Journal of …, 2007 - Elsevier
Purpose: Cisplatin chemo-irradiation is increasingly used in locally advanced squamous cell
carcinoma of the head and neck. The objective of this study is to determine risk factors of
ototoxicity due to intra-arterial high-dose cisplatin chemoradiation. Methods and Materials: A
prospective analysis of hearing thresholds at low and (ultra) high frequencies obtained
before, during, and after treatment in 146 patients. Treatment consisted of intra-arterial
infusion of high-dose cisplatin (150 mg/m2, four courses) with sodium thiosulfate rescue and …
carcinoma of the head and neck. The objective of this study is to determine risk factors of
ototoxicity due to intra-arterial high-dose cisplatin chemoradiation. Methods and Materials: A
prospective analysis of hearing thresholds at low and (ultra) high frequencies obtained
before, during, and after treatment in 146 patients. Treatment consisted of intra-arterial
infusion of high-dose cisplatin (150 mg/m2, four courses) with sodium thiosulfate rescue and …