Lovastatin protects against cisplatin-induced hearing loss in mice
K Fernandez, KK Spielbauer, A Rusheen, L Wang… - Hearing research, 2020 - Elsevier
Cisplatin is used to treat a variety of solid tumors in both children and adults. However,
cisplatin has serious side-effects, some of which may permanently affect patients' quality of
life following treatment, such as ototoxicity. There is currently no FDA-approved therapy for
the prevention or treatment of cisplatin-induced hearing loss. Herein we examine the
potential for statins to prevent cisplatin-induced ototoxicity. Statins, a class of drugs
commonly used to prevent or manage hypercholesterolemia, have been of clinical utility for …
cisplatin has serious side-effects, some of which may permanently affect patients' quality of
life following treatment, such as ototoxicity. There is currently no FDA-approved therapy for
the prevention or treatment of cisplatin-induced hearing loss. Herein we examine the
potential for statins to prevent cisplatin-induced ototoxicity. Statins, a class of drugs
commonly used to prevent or manage hypercholesterolemia, have been of clinical utility for …