Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss
P Bertolini, M Lassalle, G Mercier… - Journal of pediatric …, 2004 - journals.lww.com
Objectives: The purpose of this study was to evaluate the severity of hearing loss after
cisplatin and/or carboplatin treatment in young children and to analyze its evolution and its
relation to different therapy schedules. Methods: One hundred twenty patients treated in the
Pediatrics Department at the Institut Gustave-Roussy from 1987 to 1997 for neuroblastoma,
osteosarcoma, hepatoblastoma, or germ cell tumors were analyzed. Median age at
diagnosis was 2.6 (range 0–17) years. Median follow-up was 7 (1–13) years. Chemotherapy …
cisplatin and/or carboplatin treatment in young children and to analyze its evolution and its
relation to different therapy schedules. Methods: One hundred twenty patients treated in the
Pediatrics Department at the Institut Gustave-Roussy from 1987 to 1997 for neuroblastoma,
osteosarcoma, hepatoblastoma, or germ cell tumors were analyzed. Median age at
diagnosis was 2.6 (range 0–17) years. Median follow-up was 7 (1–13) years. Chemotherapy …