Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals
R Wang, G Wang, MJ Ricard, B Ferris… - Chest, 2010 - Elsevier
Background The aldo-keto reductase (AKR) gene superfamily codes for monomeric, soluble
reduced nicotinamide adenine dinucleotide phosphate-dependent oxidoreductases that
mediate elimination reactions. AKR1B10, an AKR that eliminates retinals, has been
observed as upregulated in squamous metaplasia and non-small cell lung cancer and has
been suggested as a diagnostic marker specific to tobacco-related carcinogenesis. We
hypothesized that upregulation of AKR1B10 expression may be initiated in healthy smokers …
reduced nicotinamide adenine dinucleotide phosphate-dependent oxidoreductases that
mediate elimination reactions. AKR1B10, an AKR that eliminates retinals, has been
observed as upregulated in squamous metaplasia and non-small cell lung cancer and has
been suggested as a diagnostic marker specific to tobacco-related carcinogenesis. We
hypothesized that upregulation of AKR1B10 expression may be initiated in healthy smokers …