The biogenesis of multivesicular endosomes
J Gruenberg, H Stenmark - Nature reviews Molecular cell biology, 2004 - nature.com
Nature reviews Molecular cell biology, 2004•nature.com
Recent progress has been made in our understanding of the molecular mechanisms that
regulate the biogenesis of multivesicular transport intermediates in the degradation pathway
that leads to lysosomes. Here, we discuss recent work that uncovers some of the
mechanisms that cause both membrane invagination within these newly forming
intermediates and the detachment of these intermediates from early endosomal membranes.
regulate the biogenesis of multivesicular transport intermediates in the degradation pathway
that leads to lysosomes. Here, we discuss recent work that uncovers some of the
mechanisms that cause both membrane invagination within these newly forming
intermediates and the detachment of these intermediates from early endosomal membranes.
Abstract
Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.
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