Evidence on the central mechanisms mediating amphetamine-induced anorexia, locomotion, and stereotypy is reviewed, with the findings suggesting the following conclusions. The central mediation of amphetamine's anorexic effect involves both dopaminergic (nigrostriatal system) and noradrenergic (lateral hypothalamus and ascending noradrenergic pathways) processes, with amygdala-hypothalamic connections and cortical sites serving a possible addition role in such an effect of the drug. The central mediation of amphetamine's locomotor-stimulating effect involves both dopaminergic (nigrostriatal and mesolimbic systems) and noradrenergic (ascending noradrenergic pathways as well as their hypothalamic and cortical projections) processes. While the role of amygdala sites in amphetamine-induced locomotion is unclear, additional central processes exert inhibitory influences on the mediation of such an effect of the drug. The central mediation of amphetamine's stereotypical effect involves a rather exclusive role of the dopaminergic nigrostriatal system, although such mediational principles are influenced by additional inhibitory processes. Finally, evidence on the overlap and dissociation of central processes associated with these behavioral effects of the drug is discussed and the importance of such principles to amphetamine studies briefly indicated.