Crizotinib (PF-2341066) induces apoptosis due to downregulation of pSTAT3 and BCL-2 family proteins in NPM-ALK+ anaplastic large cell lymphoma
FS Hamedani, M Cinar, Z Mo, MA Cervania, HM Amin… - Leukemia research, 2014 - Elsevier
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is an aberrant fusion gene product
with tyrosine kinase activity and is expressed in substantial subset of anaplastic large cell
lymphomas (ALCL). It has been shown that NPM-ALK binds to and activates signal
transducer and activator of transcription 3 (STAT3). Although NPM-ALK+ ALCL overall
shows a better prognosis, there is a sub-group of patients who relapses and is resistant to
conventional chemotherapeutic regimens. NPM-ALK is a potential target for small molecule …
with tyrosine kinase activity and is expressed in substantial subset of anaplastic large cell
lymphomas (ALCL). It has been shown that NPM-ALK binds to and activates signal
transducer and activator of transcription 3 (STAT3). Although NPM-ALK+ ALCL overall
shows a better prognosis, there is a sub-group of patients who relapses and is resistant to
conventional chemotherapeutic regimens. NPM-ALK is a potential target for small molecule …