The control of immune responses against self and nonharmful environmental antigens is of
critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players
of such immune regulation and their deficiency and dysfunction are associated with various
immune disorders, such as autoimmunity and allergy. It is therefore essential to understand
the molecular mechanisms that make up Treg cell characteristics; that is, how their unique
gene expression profile is regulated at transcriptional and epigenetic levels. In this chapter …